Metabolism and Cardiovascular signaling

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Principal investigator: Dr. Sergio Lavandero
Associated researchers: Mario Chiong, Zully Pedrozo, Lorena Garcia, Alfredo Criollo, Rodrigo Troncoso, Guillermo Díaz-Araya.
Cardiovascular remodeling involves genetic changes, Molecular and cellular in cardiomyocytes and vascular smooth muscle cells (VSMC), It produces progressive structural and functional alterations. Started as a mechanism for adaptation, This process contributes to the pathophysiology of cardiovascular diseases. Therapies aimed at countering the common underlying mechanisms have been effective in mitigating or even prevent cardiovascular remodeling. However, Despite this success, these therapies have not succeeded in reducing the progression of heart failure. Recently, cell metabolism has emerged as a new mechanism involved in the genesis and progression of cardiovascular disease. However, little is known of how metabolic change in heart cells and VSMC occurs, and its role in the genesis and progression of cardiovascular disease. We hypothesize that "cardiovascular metabolism is involved in the genesis and progression of cardiovascular diseases". Our specific objectives are:

1.Evaluar el papel de la dinámica mitocondrial en el control del metabolismo cardiaco y VSMC y su papel en el remodelado cardiovascular.
2.Evaluar el papel de la interacción mitocondria-retículo endoplásmico en el control del metabolismo cardiaco y VSMC y su papel en el remodelado cardiovascular.
3.Investigar las vías de señalización implicadas en el control del metabolismo cardiaco y VSMC por angiotensina-(1-9), insulin, GLP-1 and IGF-1.
4.Evaluar el valor pronóstico de los niveles plasmáticos de IGF-1, insulin, GLP-1 and exosomes in the incidence of cardiovascular disease in the cohort of the Maule.