Seminario ACCDiS 30 de Noviembre: Exosomes and Cardioprotection Dr. Jaime Riquelme Meléndez
El Centro Avanzado de Enfermedades Crónicas tiene el agrado de invitarlos a participar en su Ciclo de Seminarios Anuales 2017
Exosomes and Cardioprotection
Dr. Jaime Riquelme Meléndez
Doctor en Farmacología
Laboratorio de Transducción de Señales Moleculares
Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile
Jueves 30 de Noviembre 2017
Resumen de la charla:
Myocardial infarction is one of the leading causes of death worldwide. After an ischemic event, timely reperfusion is of paramount importance. However, this process itself may induce further damage. Currently, there are several ways to protect the myocardium from ischemia/reperfusion injury. Nonetheless, the translation of these cardioprotective manoeuvres from bench to bedside has proven difficult. The current disconnection between basic and clinical science may be explained by the presence of multiple confounding factors in clinical trials, such as co-morbidities, co-medications or ageing.
Exosomes are nano-vesicles capable of carrying proteins, RNA or MicroRNA from one cell to another, generating great interest in their potential as cardioprotective agents. Considering it has been shown that exosomes can protect the heart from ischemia/reperfusion injury, we hypothesized whether these extracellular vesicles can maintain their cardioprotective power in pathological contexts.
Our results show that protection mediated by exosomes may be impaired in the context of type II diabetes, but further studies are indeed required to improve isolation and characterization methods in order understand and eventually harness the full power of these enigmatic vesicles.